| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human NKG2C/CD159c-N-His & Avi protein was developed from hek293 cells and has a target region of N-His & Avi. For use in research applications. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Endotoxin: |
Less than 1EU per Mu g by the LAL method. |
| Gene Symbol: |
KLRC2 |
| Gene ID: |
3822 |
| Uniprot ID: |
NKG2C_HUMAN |
| Immunogen Region: |
Glu98-Leu231 |
| Immunogen: |
Recombinant Human NKG2C/CD159c Protein is expressed from Expi293 with His tag and Avi tag at the N-terminal.；It contains Glu98-Leu231 |
| Function | Immune activating receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib HLA-E loaded with signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules, likely playing a role in the generation and effector functions of adaptive natural killer (NK) cells and in maternal-fetal tolerance during pregnancy. Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection. Upon HLA-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation. |
| Protein Name | Nkg2-C Type Ii Integral Membrane ProteinCd159 Antigen-Like Family Member CNk Cell Receptor CNkg2-C-Activating Nk ReceptorCd Antigen Cd159c |
| Database Links | Reactome: R-HSA-2172127Reactome: R-HSA-2424491 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | Nkg2-C Type Ii Integral Membrane Protein proteinCd159 Antigen-Like Family Member C proteinNk Cell Receptor C proteinNkg2-C-Activating Nk Receptor proteinCd Antigen Cd159c proteinKLRC2 proteinNKG2C protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
