• Human NINJ1 (Ninjurin 1) Sandwich ELISA Kit Ready-To-Use (STJE0017360)

Human NINJ1 (Ninjurin 1) Sandwich ELISA Kit Ready-To-Use (STJE0017360)

SKU:
STJE0017360

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.111ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This NINJ1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: NINJ1
Gene ID: 4814
Uniprot ID: NINJ1_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Widely expressed in both adult and embryonic tissues, primarily those of epithelial origin.
Post Translational Modifications Ninjurin-1: Cleaved by MMP9 protease to generate the Secreted ninjurin-1 form. Ninjurin-1: N-linked glycosylation is required for homooligomerization.
Function Ninjurin-1: Effector of necroptotic and pyroptotic programmed cell death that mediates plasma membrane rupture (cytolysis). Acts downstream of Gasdermin (GSDMA, GSDMB, GSDMC, GSDMD, or GSDME) or MLKL during pyroptosis or necroptosis, respectively: oligomerizes in response to death stimuli and promotes plasma membrane rupture by introducing hydrophilic faces of 2 alpha helices into the hydrophobic membrane, leading to release intracellular molecules named damage-associated molecular patterns (DAMPs) that propagate the inflammatory response. Acts as a regulator of Toll-like receptor 4 (TLR4) signaling triggered by lipopolysaccharide (LPS) during systemic inflammation.directly binds LPS. Involved in leukocyte migration during inflammation by promoting transendothelial migration of macrophages via homotypic binding. Promotes the migration of monocytes across the brain endothelium to central nervous system inflammatory lesions. Also acts as a homophilic transmembrane adhesion molecule involved in various processes such as axonal growth, cell chemotaxis and angiogenesis. Promotes cell adhesion by mediating homophilic interactions via its extracellular N-terminal adhesion motif (N-NAM). Involved in the progression of the inflammatory stress by promoting cell-to-cell interactions between immune cells and endothelial cells. Plays a role in nerve regeneration by promoting maturation of Schwann cells. Acts as a regulator of angiogenesis. Promotes the formation of new vessels by mediating the interaction between capillary pericyte cells and endothelial cells. Promotes osteoclasts development by enhancing the survival of prefusion osteoclasts. Also involved in striated muscle growth and differentiation. Secreted ninjurin-1: Secreted form generated by cleavage, which has chemotactic activity. Acts as an anti-inflammatory mediator by promoting monocyte recruitment, thereby ameliorating atherosclerosis.
Protein Name Ninjurin-1
Hninj1
Nerve Injury-Induced Protein 1 Cleaved Into - Secreted Ninjurin-1
Soluble Ninjurin-1
Database Links
Cellular Localisation Ninjurin-1: Cell Membrane
Multi-Pass Membrane Protein
Synaptic Cell Membrane
Secreted Ninjurin-1: Secreted
Alternative ELISA Names Ninjurin-1 ELISA kit
Hninj1 ELISA kit
Nerve Injury-Induced Protein 1 Cleaved Into - Secreted Ninjurin-1 ELISA kit
Soluble Ninjurin-1 ELISA kit
NINJ1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance