• Human ACO1 (Aconitase 1) Sandwich ELISA Kit Ready-To-Use (STJE0013228)

Human ACO1 (Aconitase 1) Sandwich ELISA Kit Ready-To-Use (STJE0013228)

SKU:
STJE0013228

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.115ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This ACO1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: ACO1
Gene ID: 48
Uniprot ID: ACOHC_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications
Function Bifunctional iron sensor that switches between 2 activities depending on iron availability. Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization. Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA. Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate.
Protein Name Cytoplasmic Aconitate Hydratase
Aconitase
Citrate Hydro-Lyase
Ferritin Repressor Protein
Iron Regulatory Protein 1
Irp1
Iron-Responsive Element-Binding Protein 1
Ire-Bp 1
Database Links Reactome: R-HSA-917937
Cellular Localisation Cytoplasm
Cytosol
Alternative ELISA Names Cytoplasmic Aconitate Hydratase ELISA kit
Aconitase ELISA kit
Citrate Hydro-Lyase ELISA kit
Ferritin Repressor Protein ELISA kit
Iron Regulatory Protein 1 ELISA kit
Irp1 ELISA kit
Iron-Responsive Element-Binding Protein 1 ELISA kit
Ire-Bp 1 ELISA kit
ACO1 ELISA kit
IREB1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance