| Post Translational Modifications | Phosphorylated by RPS6KA1.followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation. |
| Function | Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation. |
| Protein Name | Nf-Kappa-B Inhibitor BetaNf-Kappa-BibI-Kappa-B-BetaIkb-BIkb-BetaIkappabbetaThyroid Receptor-Interacting Protein 9Tr-Interacting Protein 9Trip-9 |
| Database Links | Reactome: R-HSA-1169091Reactome: R-HSA-1810476Reactome: R-HSA-445989Reactome: R-HSA-933542 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Nf-Kappa-B Inhibitor Beta proteinNf-Kappa-Bib proteinI-Kappa-B-Beta proteinIkb-B proteinIkb-Beta proteinIkappabbeta proteinThyroid Receptor-Interacting Protein 9 proteinTr-Interacting Protein 9 proteinTrip-9 proteinNFKBIB proteinIKBB proteinTRIP9 protein |
Information sourced from Uniprot.org
