| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human NFKBIA-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | NFKBIA |
| Gene ID: | 4792 |
| Uniprot ID: | IKBA_HUMAN |
| Immunogen Region: | Lys67-Glu302 |
| Immunogen: | Homo sapiens (Human) |
| Function | Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals. On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. |
| Protein Name | Nf-Kappa-B Inhibitor AlphaI-Kappa-B-AlphaIkb-AlphaIkappabalphaMajor Histocompatibility Complex Enhancer-Binding Protein Mad3 |
| Database Links | Reactome: R-HSA-1169091Reactome: R-HSA-1810476Reactome: R-HSA-202424Reactome: R-HSA-209560Reactome: R-HSA-2871837Reactome: R-HSA-445989Reactome: R-HSA-4755510Reactome: R-HSA-5603029Reactome: R-HSA-5607764Reactome: R-HSA-5689880Reactome: R-HSA-9020702Reactome: R-HSA-933542Reactome: R-HSA-9692916 |
| Cellular Localisation | CytoplasmNucleusShuttles Between The Nucleus And The Cytoplasm By A Nuclear Localization Signal (Nls) And A Crm1-Dependent Nuclear Export |
| Alternative Protein Names | Nf-Kappa-B Inhibitor Alpha proteinI-Kappa-B-Alpha proteinIkb-Alpha proteinIkappabalpha proteinMajor Histocompatibility Complex Enhancer-Binding Protein Mad3 proteinNFKBIA proteinIKBA proteinMAD3 proteinNFKBI protein |
Information sourced from Uniprot.org
