Human NEU1/Sialidase-1 protein (Recombinant) (C-His) (STJP005886)

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STJP005886
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human NEU1/Sialidase-1-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: NEU1
Gene ID: 4758
Uniprot ID: NEUR1_HUMAN
Immunogen Region: Ala47-Leu415
Immunogen: Homo sapiens (Human)
Post Translational Modifications N-glycosylated. Phosphorylation of tyrosine within the internalization signal results in inhibition of sialidase internalization and blockage on the plasma membrane.
Function Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage.
Protein Name Sialidase-1
Acetylneuraminyl Hydrolase
G9 Sialidase
Lysosomal Sialidase
N-Acetyl-Alpha-Neuraminidase 1
Database Links Reactome: R-HSA-4085001
Reactome: R-HSA-4341670
Reactome: R-HSA-6798695
Reactome: R-HSA-9840310
Cellular Localisation Lysosome Membrane
Peripheral Membrane Protein
Lumenal Side
Lysosome Lumen
Cell Membrane
Cytoplasmic Vesicle
Lysosome
Localized Not Only On The Inner Side Of The Lysosomal Membrane And In The Lysosomal Lumen
But Also On The Plasma Membrane And In Intracellular Vesicles
Alternative Protein Names Sialidase-1 protein
Acetylneuraminyl Hydrolase protein
G9 Sialidase protein
Lysosomal Sialidase protein
N-Acetyl-Alpha-Neuraminidase 1 protein
NEU1 protein
NANH protein

Information sourced from Uniprot.org

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