• Human Nesp1 (Nesprin 1) Sandwich ELISA Kit (STJE0010922)

Human Nesp1 (Nesprin 1) Sandwich ELISA Kit (STJE0010922)

SKU:
STJE0010922

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.105ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This Nesp1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: SYNE1
Gene ID: 23345
Uniprot ID: SYNE1_HUMAN
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Expressed in HeLa, A431, A172 and HaCaT cells (at protein level). Widely expressed. Highly expressed in skeletal and smooth muscles, heart, spleen, peripheral blood leukocytes, pancreas, cerebellum, stomach, kidney and placenta. Isoform GSRP-56 is predominantly expressed in heart and skeletal muscle (at protein level).
Post Translational Modifications The disulfid bond with SUN1 or SUN2 is required for stability of the respective LINC complex under tensile forces.
Function Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes.SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis.a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette.
Protein Name Nesprin-1
Enaptin
Kash Domain-Containing Protein 1
Kash1
Myocyte Nuclear Envelope Protein 1
Myne-1
Nuclear Envelope Spectrin Repeat Protein 1
Synaptic Nuclear Envelope Protein 1
Syne-1
Database Links Reactome: R-HSA-1221632
Cellular Localisation Nucleus Outer Membrane
Single-Pass Type Iv Membrane Protein
Cytoplasmic Side
Nucleus
Nucleus Envelope
Cytoplasm
Cytoskeleton
Myofibril
Sarcomere
The Largest Part Of The Protein Is Cytoplasmic
While Its C-Terminal Part Is Associated With The Nuclear Envelope
Most Probably The Outer Nuclear Membrane
In Skeletal And Smooth Muscles
A Significant Amount Is Found In The Sarcomeres
In Myoblasts
Relocalized From The Nuclear Envelope To The Nucleus And Cytoplasm During Cell Differentiation
Isoform Gsrp-56: Golgi Apparatus
Alternative ELISA Names Nesprin-1 ELISA kit
Enaptin ELISA kit
Kash Domain-Containing Protein 1 ELISA kit
Kash1 ELISA kit
Myocyte Nuclear Envelope Protein 1 ELISA kit
Myne-1 ELISA kit
Nuclear Envelope Spectrin Repeat Protein 1 ELISA kit
Synaptic Nuclear Envelope Protein 1 ELISA kit
Syne-1 ELISA kit
SYNE1 ELISA kit
C6orf98 ELISA kit
KIAA0796 ELISA kit
KIAA1262 ELISA kit
KIAA1756 ELISA kit
MYNE1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance