• Human NEFH (Neurofilament, Heavy Polypeptide) Sandwich ELISA Kit Ready-To-Use (STJE0017293)

Human NEFH (Neurofilament, Heavy Polypeptide) Sandwich ELISA Kit Ready-To-Use (STJE0017293)

SKU:
STJE0017293

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 5.2pg/mL
Detection Limit: 15.6-1000pg/mL
Short Description: This NEFH Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: NEFH
Gene ID: 4744
Uniprot ID: NFH_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications There are a number of repeats of the tripeptide K-S-P, NFH is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFH results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber. Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincidentally with a change in the neurofilament function. Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization.
Function Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks.
Protein Name Neurofilament Heavy Polypeptide
Nf-H
200 Kda Neurofilament Protein
Neurofilament Triplet H Protein
Database Links
Cellular Localisation Cytoplasm
Cytoskeleton
Cell Projection
Axon
Alternative ELISA Names Neurofilament Heavy Polypeptide ELISA kit
Nf-H ELISA kit
200 Kda Neurofilament Protein ELISA kit
Neurofilament Triplet H Protein ELISA kit
NEFH ELISA kit
KIAA0845 ELISA kit
NFH ELISA kit
output

Information sourced from Uniprot.org

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