| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.27ng/mL |
| Detection Limit: |
0.781-50ng/mL |
| Short Description: |
This MX1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
3 hrs |
| Gene Symbol: |
MX1 |
| Gene ID: |
4599 |
| Uniprot ID: |
MX1_HUMAN |
| Immunogen Region: |
Ready-To-Use |
| Sample Type: |
tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | ISGylated. |
| Function | Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs. |
| Protein Name | Interferon-Induced Gtp-Binding Protein Mx1Interferon-Induced Protein P78Ifi-78kInterferon-Regulated Resistance Gtp-Binding Protein MxaMyxoma Resistance Protein 1Myxovirus Resistance Protein 1 Cleaved Into - Interferon-Induced Gtp-Binding Protein Mx1 - N-Terminally Processed |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-909733 |
| Cellular Localisation | CytoplasmEndoplasmic Reticulum MembranePeripheral Membrane ProteinCytoplasmic SidePerinuclear RegionBinds Preferentially To Negatively Charged PhospholipidsColocalizes With Cchfv Protein N In The Perinuclear RegionIsoform 2: CytoplasmNucleusTranslocates Into The Nuclei Of Hsv-1 Infected Cells |
| Alternative ELISA Names | Interferon-Induced Gtp-Binding Protein Mx1 ELISA kitInterferon-Induced Protein P78 ELISA kitIfi-78k ELISA kitInterferon-Regulated Resistance Gtp-Binding Protein Mxa ELISA kitMyxoma Resistance Protein 1 ELISA kitMyxovirus Resistance Protein 1 Cleaved Into - Interferon-Induced Gtp-Binding Protein Mx1 - N-Terminally Processed ELISA kitMX1 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
