| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
5.4pg/mL |
| Detection Limit: |
15.6-1000pg/mL |
| Short Description: |
This MPIF1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
CCL23 |
| Gene ID: |
6368 |
| Uniprot ID: |
CCL23_HUMAN |
| Sample Type: |
serum, plasma or other biological fluids. |
| Tissue Specificity | High levels in adult lung, liver, skeletal muscle and pancreas. Moderate levels in fetal liver, adult bone marrow and placenta. The short form is the major species and the longer form was detected only in very low abundance. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are found in high levels in synovial fluids from rheumatoid patients. |
| Post Translational Modifications | The N-terminal is proteolytically cleaved by proteases associated with inflammatory responses. The processed forms, CCL23(19-99), CCL23(22-99), CCL23(27-99) and CCL23(30-99) exhibit increase in CCR1-mediated signaling and chemotaxis assays in vitro. |
| Function | Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than CCL23. |
| Protein Name | C-C Motif Chemokine 23Ck-Beta-8Ckb-8Macrophage Inflammatory Protein 3Mip-3Myeloid Progenitor Inhibitory Factor 1Mpif-1Small-Inducible Cytokine A23 Cleaved Into - Ccl23(19-99 - Ccl23(22-99 - Ccl23(27-99 - Ccl23(30-99 |
| Database Links | Reactome: R-HSA-416476 P55773-2Reactome: R-HSA-418594 P55773-2Reactome: R-HSA-444473 P55773-2 |
| Cellular Localisation | Secreted |
| Alternative ELISA Names | C-C Motif Chemokine 23 ELISA kitCk-Beta-8 ELISA kitCkb-8 ELISA kitMacrophage Inflammatory Protein 3 ELISA kitMip-3 ELISA kitMyeloid Progenitor Inhibitory Factor 1 ELISA kitMpif-1 ELISA kitSmall-Inducible Cytokine A23 Cleaved Into - Ccl23(19-99 - Ccl23(22-99 - Ccl23(27-99 - Ccl23(30-99 ELISA kitCCL23 ELISA kitMIP3 ELISA kitMPIF1 ELISA kitSCYA23 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
