• Human MMP-3 protein (Active Recombinant) (C-His) (STJP000992)
  • Human MMP-3 protein (Active Recombinant) (C-His) (STJP000992)
  • Human MMP-3 protein (Active Recombinant) (C-His) (STJP000992)
  • Human MMP-3 protein (Active Recombinant) (C-His) (STJP000992)

Human MMP-3 protein (Active Recombinant) (C-His) (STJP000992)

SKU:
STJP000992

£114.50 - £408.50
Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Active Recombinant-Human MMP-3-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Supplied as a 0.22 Mu m filtered solution in 20mM TRIS, 150mM NaCl, 0.05% Brij-35 (w/v) , 10% Glycerol, pH 7.5. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK (Dnp)-NH2. The specific activity is >515 pmol/min/Mu g.
Gene Symbol: MMP3
Gene ID: 4314
Uniprot ID: MMP3_HUMAN
Immunogen Region: Tyr18-Cys477
Immunogen: Recombinant Human MMP-3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Tyr18-Cys477) of human MMP-3 (Accession #NP_002413.1) fused with a 6×His tag at the C-terminus.
Post Translational Modifications Directly cleaved by HTRA2 to produce active form.
Function Metalloproteinase with a rather broad substrate specificity that can degrade fibronectin, laminin, gelatins of type I, III, IV, and V.collagens III, IV, X, and IX, and cartilage proteoglycans. Activates different molecules including growth factors, plasminogen or other matrix metalloproteinases such as MMP9. Once released into the extracellular matrix (ECM), the inactive pro-enzyme is activated by the plasmin cascade signaling pathway. Acts also intracellularly. For example, in dopaminergic neurons, gets activated by the serine protease HTRA2 upon stress and plays a pivotal role in DA neuronal degeneration by mediating microglial activation and alpha-synuclein/SNCA cleavage. In addition, plays a role in immune response and possesses antiviral activity against various viruses such as vesicular stomatitis virus, influenza A virus (H1N1) and human herpes virus 1. Mechanistically, translocates from the cytoplasm into the cell nucleus upon virus infection to influence NF-kappa-B activities.
Protein Name Stromelysin-1
Sl-1
Matrix Metalloproteinase-3
Mmp-3
Transin-1
Database Links Reactome: R-HSA-1442490
Reactome: R-HSA-1474228
Reactome: R-HSA-1592389
Reactome: R-HSA-2022090
Reactome: R-HSA-2179392
Reactome: R-HSA-6785807
Reactome: R-HSA-9009391
Cellular Localisation Secreted
Extracellular Space
Extracellular Matrix
Nucleus
Cytoplasm
Alternative Protein Names Stromelysin-1 protein
Sl-1 protein
Matrix Metalloproteinase-3 protein
Mmp-3 protein
Transin-1 protein
MMP3 protein
STMY1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance