Human MCRS1 protein (Recombinant) (N-His) (STJP009690)

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STJP009690
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human MCRS1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: MCRS1
Gene ID: 10445
Uniprot ID: MCRS1_HUMAN
Immunogen Region: Gln344-Gln462
Immunogen: Homo sapiens (Human)
Post Translational Modifications Ubiquitinated by UBR5 when not assembled in the INO80 complex, leading to its degradation: UBR5 recognizes and binds a degron that is not accessible when MCRS1 is part of the INO80 complex.
Function Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity. Binds to G-quadruplex structures in mRNA. Binds to RNA homomer poly(G) and poly(U).
Protein Name Microspherule Protein 1
58 Kda Microspherule Protein
Cell Cycle-Regulated Factor P78
Ino80 Complex Subunit J
Mcrs2
Database Links Reactome: R-HSA-3214847
Reactome: R-HSA-5689603
Reactome: R-HSA-5696394
Reactome: R-HSA-9772755
Cellular Localisation Nucleus
Nucleolus
Cytoplasm
In Microspherules In The Nucleolus
Alternative Protein Names Microspherule Protein 1 protein
58 Kda Microspherule Protein protein
Cell Cycle-Regulated Factor P78 protein
Ino80 Complex Subunit J protein
Mcrs2 protein
MCRS1 protein
INO80Q protein
MSP58 protein

Information sourced from Uniprot.org

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