• Human MARCKSL1 (MARCKS Related Protein) Sandwich ELISA Kit Ready-To-Use (STJE0016878)

Human MARCKSL1 (MARCKS Related Protein) Sandwich ELISA Kit Ready-To-Use (STJE0016878)

SKU:
STJE0016878

Shipping:
Free Shipping
Current Stock:
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.105ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This MARCKSL1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: MARCKSL1
Gene ID: 65108
Uniprot ID: MRP_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications Phosphorylated. Phosphorylation at Ser-120 and Thr-178 is non-redundantly catalyzed by MAPK8 in vivo. Phosphorylation at Thr-148 is preferentially catalyzed by MAPK8 in vivo, but this modification can also be catalyzed by other kinases in the absence of MAPK8. May be phosphorylated by protein kinase C, which disrupts the interaction with calmodulin.
Function Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems.
Protein Name Marcks-Related Protein
Marcks-Like Protein 1
Macrophage Myristoylated Alanine-Rich C Kinase Substrate
Mac-Marcks
Macmarcks
Database Links
Cellular Localisation Cytoplasm
Cytoskeleton
Cell Membrane
Lipid-Anchor
Associates With The Membrane Via The Insertion Of The N-Terminal N-Myristoyl Chain And The Partial Insertion Of The Effector Domain
Association Of The Effector Domain With Membranes May Be Regulated By Ca(2+)/Calmodulin
Colocalizes With F-Actin At The Leading Edge Of Migrating Cells
In Prostate Cancers
Shows Strong Expression At Apical And/Or Basal Regions Of The Cell And Also Has Weak Cytoplasmic Expression
Alternative ELISA Names Marcks-Related Protein ELISA kit
Marcks-Like Protein 1 ELISA kit
Macrophage Myristoylated Alanine-Rich C Kinase Substrate ELISA kit
Mac-Marcks ELISA kit
Macmarcks ELISA kit
MARCKSL1 ELISA kit
MLP ELISA kit
MRP ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance