| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.128ng/mL |
| Detection Limit: |
0.312-20ng/mL |
| Short Description: |
This LY9 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
LY9 |
| Gene ID: |
4063 |
| Uniprot ID: |
LY9_HUMAN |
| Sample Type: |
tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Increased surface expression on T-cells of systemic lupus erythematosus (SLE) patients. |
| Post Translational Modifications | |
| Function | Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion.the costimulatory activity requires SH2D1A. Promotes recruitment of RORC to the IL-17 promoter. May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells. May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells. |
| Protein Name | T-Lymphocyte Surface Antigen Ly-9Cell Surface Molecule Ly-9Lymphocyte Antigen 9Slam Family Member 3Slamf3Signaling Lymphocytic Activation Molecule 3Cd Antigen Cd229 |
| Database Links | |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinCell Membrane |
| Alternative ELISA Names | T-Lymphocyte Surface Antigen Ly-9 ELISA kitCell Surface Molecule Ly-9 ELISA kitLymphocyte Antigen 9 ELISA kitSlam Family Member 3 ELISA kitSlamf3 ELISA kitSignaling Lymphocytic Activation Molecule 3 ELISA kitCd Antigen Cd229 ELISA kitLY9 ELISA kitCDABP0070 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
