Human LRRC32/GARP protein (Recombinant) (C-His) (STJP009522)

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STJP009522
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human LRRC32/GARP-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: LRRC32
Gene ID: 2615
Uniprot ID: LRC32_HUMAN
Immunogen Region: Met1-Asn627
Immunogen: Homo sapiens (Human)
Function Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta. Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3).
Protein Name Transforming Growth Factor Beta Activator Lrrc32
Garpin
Glycoprotein A Repetitions Predominant
Garp
Leucine-Rich Repeat-Containing Protein 32
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Surface
Alternative Protein Names Transforming Growth Factor Beta Activator Lrrc32 protein
Garpin protein
Glycoprotein A Repetitions Predominant protein
Garp protein
Leucine-Rich Repeat-Containing Protein 32 protein
LRRC32 protein
D11S833E protein

Information sourced from Uniprot.org

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