• Human LRP5 (Low Density Lipoprotein Receptor Related Protein 5) Sandwich ELISA Kit (STJE0010421)

Human LRP5 (Low Density Lipoprotein Receptor Related Protein 5) Sandwich ELISA Kit (STJE0010421)

SKU:
STJE0010421

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.118ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This LRP5 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: LRP5
Gene ID: 4041
Uniprot ID: LRP5_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Widely expressed, with the highest level of expression in the liver and in aorta.
Post Translational Modifications Phosphorylation of cytoplasmic PPPSP motifs regulates the signal transduction of the Wnt signaling pathway through acting as a docking site for AXIN1.
Function Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration. In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation. During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass. Mechanistically, the formation of the signaling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilizing beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs. Acts as a coreceptor for non-Wnt proteins, such as norrin/NDP. Binding of norrin/NDP to frizzled 4/FZD4-LRP5 receptor complex triggers beta-catenin/CTNNB1-dependent signaling known to be required for retinal vascular development. Plays a role in controlling postnatal vascular regression in retina via macrophage-induced endothelial cell apoptosis.
Protein Name Low-Density Lipoprotein Receptor-Related Protein 5
Lrp-5
Low-Density Lipoprotein Receptor-Related Protein 7
Lrp-7
Database Links Reactome: R-HSA-201681
Reactome: R-HSA-3772470
Reactome: R-HSA-4641262
Reactome: R-HSA-4641263
Reactome: R-HSA-5339717
Reactome: R-HSA-5340588
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Endoplasmic Reticulum
Chaperoned To The Plasma Membrane By Mesd
Alternative ELISA Names Low-Density Lipoprotein Receptor-Related Protein 5 ELISA kit
Lrp-5 ELISA kit
Low-Density Lipoprotein Receptor-Related Protein 7 ELISA kit
Lrp-7 ELISA kit
LRP5 ELISA kit
LR3 ELISA kit
LRP7 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance