• Human LRH1 (Liver Receptor Homolog 1) Sandwich ELISA Kit Ready-To-Use (STJE0016802)

Human LRH1 (Liver Receptor Homolog 1) Sandwich ELISA Kit Ready-To-Use (STJE0016802)

SKU:
STJE0016802

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.112ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This LRH1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: NR5A2
Gene ID: 2494
Uniprot ID: NR5A2_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Abundantly expressed in pancreas, less in liver, very low levels in heart and lung. Expressed in the Hep-G2 cell line. Isoform 1 and isoform 2 seem to be present in fetal and adult liver and Hep-G2 cells.
Post Translational Modifications Sumoylated by SUMO1 at Lys-270 during the hepatic acute phase response, leading to promote interaction with GPS2 and prevent N-Cor corepressor complex dissociation.
Function Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex. Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Activates the transcription of CYP2C38.
Protein Name Nuclear Receptor Subfamily 5 Group A Member 2
Alpha-1-Fetoprotein Transcription Factor
B1-Binding Factor
Hb1f
Cyp7a Promoter-Binding Factor
Hepatocytic Transcription Factor
Liver Receptor Homolog 1
Lrh-1
Database Links Reactome: R-HSA-210747 O00482-1
Reactome: R-HSA-383280
Reactome: R-HSA-4090294 O00482-2
Reactome: R-HSA-9018519
Cellular Localisation Nucleus
Alternative ELISA Names Nuclear Receptor Subfamily 5 Group A Member 2 ELISA kit
Alpha-1-Fetoprotein Transcription Factor ELISA kit
B1-Binding Factor ELISA kit
Hb1f ELISA kit
Cyp7a Promoter-Binding Factor ELISA kit
Hepatocytic Transcription Factor ELISA kit
Liver Receptor Homolog 1 ELISA kit
Lrh-1 ELISA kit
NR5A2 ELISA kit
B1F ELISA kit
CPF ELISA kit
FTF ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance