• Human LOXL3 (Lysyl Oxidase Like Protein 3) Sandwich ELISA Kit (STJE0010388)

Human LOXL3 (Lysyl Oxidase Like Protein 3) Sandwich ELISA Kit (STJE0010388)

SKU:
STJE0010388

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.072ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This LOXL3 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: LOXL3
Gene ID: 84695
Uniprot ID: LOXL3_HUMAN
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Isoform 1: Predominantly detected in the heart, placenta, lung, and small intestine. Isoform 2: Highly detected in the kidney, pancreas, spleen, and thymus, and is absent in lung. In eye, present in all layers of corneas as well as in the limbus and conjunctiva (at protein level).
Post Translational Modifications The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
Function Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins. Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin. Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ). Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity. Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated. Also able to catalyze deacetylation of lysine residues on STAT3. Isoform 1: Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type VIII. Isoform 2: Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type IV.
Protein Name Lysyl Oxidase Homolog 3
Lysyl Oxidase-Like Protein 3
Database Links Reactome: R-HSA-1566948
Reactome: R-HSA-2243919
Cellular Localisation Secreted
Extracellular Space
Cytoplasm
Nucleus
It Is Unclear How Loxl3 Is Both Intracellular (Cytoplasmic And Nuclear) And Extracellular: It Contains A Clear Signal Sequence And Is Predicted To Localize In The Extracellular Medium
However
The Intracellular Location Is Clearly Reported And At Least Another Protein Of The Family (Loxl2) Also Has Intracellular And Extracellular Localization Despite The Presence Of A Signal Sequence
Isoform 1: Secreted
Isoform 2: Cytoplasm
Alternative ELISA Names Lysyl Oxidase Homolog 3 ELISA kit
Lysyl Oxidase-Like Protein 3 ELISA kit
LOXL3 ELISA kit
LOXL ELISA kit
output

Information sourced from Uniprot.org

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