Tissue Specificity | Expressed in a wide range of adult tissues including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, lung and peripheral blood leukocytes. |
Post Translational Modifications | Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome. |
Function | Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. |
Protein Name | Lim Domain-Binding Protein 1Ldb-1Carboxyl-Terminal Lim Domain-Binding Protein 2Clim-2Lim Domain-Binding Factor Clim2Hldb1Nuclear Lim Interactor |
Database Links | Reactome: R-HSA-8939236Reactome: R-HSA-9010553Reactome: R-HSA-9733709Reactome: R-HSA-9752946 |
Cellular Localisation | NucleusColocalizes With Slk At Leading Edges |
Alternative ELISA Names | Lim Domain-Binding Protein 1 ELISA kitLdb-1 ELISA kitCarboxyl-Terminal Lim Domain-Binding Protein 2 ELISA kitClim-2 ELISA kitLim Domain-Binding Factor Clim2 ELISA kitHldb1 ELISA kitNuclear Lim Interactor ELISA kitLDB1 ELISA kitCLIM2 ELISA kit |
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Information sourced from Uniprot.org