• Human KISS1R (Kisspeptin Receptor) Sandwich ELISA Kit (STJE0010167)

Human KISS1R (Kisspeptin Receptor) Sandwich ELISA Kit (STJE0010167)

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STJE0010167

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.126ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This KISS1R Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: KISS1R
Gene ID: 84634
Uniprot ID: KISSR_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Most highly expressed in the pancreas, placenta and spinal cord, with lower-level of expression in peripheral blood leukocytes, kidney, lung, fetal liver, stomach, small intestine, testes, spleen, thymus, adrenal glands and lymph nodes. In the adult brain, expressed in the superior frontal gyrus, putamen, caudate nucleus, cingulate gyrus, nucleus accumbens, hippocampus, pons and amygdala, as well as the hypothalamus and pituitary. Expression levels are higher in early (7-9 weeks) than term placentas. Expression levels were increased in both early placentas and molar pregnancies and were reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation. Also found in the extravillous trophoblast suggesting endocrine/paracrine activation mechanism.
Post Translational Modifications
Function Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.
Protein Name Kiss-1 Receptor
Kiss-1r
G-Protein Coupled Receptor 54
G-Protein Coupled Receptor Ot7t175
Hot7t175
Hypogonadotropin-1
Kisspeptins Receptor
Metastin Receptor
Database Links Reactome: R-HSA-375276
Reactome: R-HSA-416476
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative ELISA Names Kiss-1 Receptor ELISA kit
Kiss-1r ELISA kit
G-Protein Coupled Receptor 54 ELISA kit
G-Protein Coupled Receptor Ot7t175 ELISA kit
Hot7t175 ELISA kit
Hypogonadotropin-1 ELISA kit
Kisspeptins Receptor ELISA kit
Metastin Receptor ELISA kit
KISS1R ELISA kit
AXOR12 ELISA kit
GPR54 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance