| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.64ng/mL |
| Detection Limit: |
1.56-100ng/mL |
| Short Description: |
This KCNJ10 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
3 hrs |
| Gene Symbol: |
KCNJ10 |
| Gene ID: |
3766 |
| Uniprot ID: |
KCJ10_HUMAN |
| Immunogen Region: |
Ready-To-Use |
| Sample Type: |
tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Expressed in kidney (at protein level). |
| Post Translational Modifications | |
| Function | May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium.as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules.this process is critical for Na(+) reabsorption at the tubules. |
| Protein Name | Atp-Sensitive Inward Rectifier Potassium Channel 10Atp-Dependent Inwardly Rectifying Potassium Channel Kir4.1Inward Rectifier K(+ Channel Kir1.2Potassium Channel - Inwardly Rectifying Subfamily J Member 10 |
| Database Links | Reactome: R-HSA-1296041Reactome: R-HSA-1296067Reactome: R-HSA-997272 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneIn Kidney Distal Convoluted TubulesLocated In The Basolateral Membrane Where It Colocalizes With Kcnj16 |
| Alternative ELISA Names | Atp-Sensitive Inward Rectifier Potassium Channel 10 ELISA kitAtp-Dependent Inwardly Rectifying Potassium Channel Kir4.1 ELISA kitInward Rectifier K(+ Channel Kir1.2 ELISA kitPotassium Channel - Inwardly Rectifying Subfamily J Member 10 ELISA kitKCNJ10 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
