• Human JAM2 (Junctional Adhesion Molecule 2) Sandwich ELISA Kit Ready-To-Use (STJE0016506)

Human JAM2 (Junctional Adhesion Molecule 2) Sandwich ELISA Kit Ready-To-Use (STJE0016506)

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STJE0016506

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 12.6pg/mL
Detection Limit: 31.2-2000pg/mL
Short Description: This JAM2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: JAM2
Gene ID: 58494
Uniprot ID: JAM2_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Highly expressed in heart, placenta, lung, foreskin and lymph node. Prominently expressed on high endothelial venules and also present on the endothelia of other vessels (at protein level). Also expressed in the brain in the caudate nuclei.
Post Translational Modifications
Function Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM3 to regulate different cellular processes. Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3. Plays a central role in leukocytes extravasation by facilitating not only transmigration but also tethering and rolling of leukocytes along the endothelium. Tethering and rolling of leukocytes are dependent on the binding by JAM2 of the integrin alpha-4/beta-1. Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation. Also functions as an inhibitory somatodendritic cue that prevents the myelination of non-axonal parts of neurons. During myogenesis, it is involved in myocyte fusion. May also play a role in angiogenesis.
Protein Name Junctional Adhesion Molecule B
Jam-B
Junctional Adhesion Molecule 2
Jam-2
Vascular Endothelial Junction-Associated Molecule
Ve-Jam
Cd Antigen Cd322
Database Links Reactome: R-HSA-202733
Reactome: R-HSA-216083
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Junction
Tight Junction
Localized At Tight Junctions Of Both Epithelial And Endothelial Cells
Specifically Localized Within The Somatodendritic Compartment Of Neurons And Excluded From The Axon
Alternative ELISA Names Junctional Adhesion Molecule B ELISA kit
Jam-B ELISA kit
Junctional Adhesion Molecule 2 ELISA kit
Jam-2 ELISA kit
Vascular Endothelial Junction-Associated Molecule ELISA kit
Ve-Jam ELISA kit
Cd Antigen Cd322 ELISA kit
JAM2 ELISA kit
C21orf43 ELISA kit
VEJAM ELISA kit
UNQ219 ELISA kit
PRO245 ELISA kit
output

Information sourced from Uniprot.org

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