| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.042ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This IRF9 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
IRF9 |
| Gene ID: |
10379 |
| Uniprot ID: |
IRF9_HUMAN |
| Sample Type: |
tissue homogenates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | (Microbial infection) Ubiquitinated by Herpes simplex virus 2 E3 ubiquitin ligase ICP22. |
| Function | Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. |
| Protein Name | Interferon Regulatory Factor 9Irf-9Ifn-Alpha-Responsive Transcription Factor SubunitIsgf3 P48 SubunitInterferon-Stimulated Gene Factor 3 GammaIsgf-3 GammaTranscriptional Regulator Isgf3 Subunit Gamma |
| Database Links | Reactome: R-HSA-877300Reactome: R-HSA-909733 |
| Cellular Localisation | CytoplasmNucleusTranslocated Into The Nucleus Upon Activation By Ifn-Alpha/Beta |
| Alternative ELISA Names | Interferon Regulatory Factor 9 ELISA kitIrf-9 ELISA kitIfn-Alpha-Responsive Transcription Factor Subunit ELISA kitIsgf3 P48 Subunit ELISA kitInterferon-Stimulated Gene Factor 3 Gamma ELISA kitIsgf-3 Gamma ELISA kitTranscriptional Regulator Isgf3 Subunit Gamma ELISA kitIRF9 ELISA kitISGF3G ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
