| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.23ng/mL |
| Detection Limit: |
0.781-50ng/mL |
| Short Description: |
This IRAK3 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
IRAK3 |
| Gene ID: |
11213 |
| Uniprot ID: |
IRAK3_HUMAN |
| Sample Type: |
serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | Expressed in eosinophils, dendritic cells and/or monocytes (at protein level). Expressed predominantly in peripheral blood lymphocytes. |
| Post Translational Modifications | |
| Function | Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors. Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells. |
| Protein Name | Interleukin-1 Receptor-Associated Kinase 3Irak-3Il-1 Receptor-Associated Kinase MIrak-MInactive Il-1 Receptor-Associated Kinase 3 |
| Database Links | Reactome: R-HSA-166058Reactome: R-HSA-9020702 |
| Cellular Localisation | CytoplasmNucleusIn Dendritic CellsTranslocates Into The Nucleus Upon Il33 Stimulation |
| Alternative ELISA Names | Interleukin-1 Receptor-Associated Kinase 3 ELISA kitIrak-3 ELISA kitIl-1 Receptor-Associated Kinase M ELISA kitIrak-M ELISA kitInactive Il-1 Receptor-Associated Kinase 3 ELISA kitIRAK3 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
