| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.059ng/mL |
| Detection Limit: |
0.156-10ng/mL |
| Short Description: |
This INPP4A Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
INPP4A |
| Gene ID: |
3631 |
| Uniprot ID: |
INP4A_HUMAN |
| Sample Type: |
tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Isoform 1 is expressed in the platelets, MEG-01 megakaryocytes and Jurkat T-cells. Isoform 2 is expressed in the brain. |
| Post Translational Modifications | |
| Function | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). Catalyzes also inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current. Isoform 4: Displays no 4-phosphatase activity for PtdIns(3,4)P2, Ins(3,4)P2, or Ins(1,3,4)P3. |
| Protein Name | Inositol Polyphosphate-4-Phosphatase Type I AInositol Polyphosphate 4-Phosphatase Type IType I Inositol 3 -4-Bisphosphate 4-Phosphatase |
| Database Links | Reactome: R-HSA-1660499Reactome: R-HSA-1660516Reactome: R-HSA-1855183 |
| Cellular Localisation | Early Endosome MembraneRecycling Endosome MembraneCell MembraneNucleusCytoplasmPostsynaptic DensityTranslocates To The Plasma Membrane Upon Egf StimulationShuttles Between The Cytoplasm And The NucleusDepending On The Cell Cycle StageWith Highest Amounts Detected In The Nucleus During The G0/G1phase |
| Alternative ELISA Names | Inositol Polyphosphate-4-Phosphatase Type I A ELISA kitInositol Polyphosphate 4-Phosphatase Type I ELISA kitType I Inositol 3 -4-Bisphosphate 4-Phosphatase ELISA kitINPP4A ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
