| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
33.5pg/mL |
| Detection Limit: |
78.1-5000pg/mL |
| Short Description: |
This ILK-1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
ILK |
| Gene ID: |
3611 |
| Uniprot ID: |
ILK_HUMAN |
| Sample Type: |
serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver. |
| Post Translational Modifications | Autophosphorylated on serine residues. |
| Function | Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Regulates cell motility by forming a complex with PARVB. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. |
| Protein Name | Integrin-Linked Protein Kinase59 Kda Serine/Threonine-Protein KinaseBeta-Integrin-Linked KinaseIlk-1Ilk-2P59ilk |
| Database Links | Reactome: R-HSA-446343Reactome: R-HSA-446353 |
| Cellular Localisation | Cell JunctionFocal AdhesionCell MembranePeripheral Membrane ProteinCytoplasmic SideCell ProjectionLamellipodiumCytoplasmMyofibrilSarcomere |
| Alternative ELISA Names | Integrin-Linked Protein Kinase ELISA kit59 Kda Serine/Threonine-Protein Kinase ELISA kitBeta-Integrin-Linked Kinase ELISA kitIlk-1 ELISA kitIlk-2 ELISA kitP59ilk ELISA kitILK ELISA kitILK1 ELISA kitILK2 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
