Human IL25/IL17E protein (Recombinant) (N-His) (STJP005982)

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STJP005982
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human IL25/IL17E-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: IL25
Gene ID: 64806
Uniprot ID: IL25_HUMAN
Immunogen Region: Met28-Gly177
Immunogen: Homo sapiens (Human)
Function Cytokine produced by various cells such as eosinophils, T-helper type 2 (Th2) cells or epithelial cells that plays a role in internal safety of adaptive immune responses by regulating cytokine production. Promotes and augments T-helper type 2 responses locally or systemically. Exerts its activity via its receptor composed of IL17RA and IL17RB for signal transduction. In turn, stimulates the JAK2-STAT5A pathway and promotes the secretion of type-2 associated cytokines including IL4, IL9 and IL13. Induces also the release of IL8, and IL6 from eosinophils through the combined activation of MAPK and NF-kappa-B pathways. Inhibits the differentiation of T-helper (Th17) cells via the production of IL4, IL5 and IL13.
Protein Name Interleukin-25
Il-25
Interleukin-17e
Il-17e
Database Links Reactome: R-HSA-448424
Cellular Localisation Secreted
Alternative Protein Names Interleukin-25 protein
Il-25 protein
Interleukin-17e protein
Il-17e protein
IL25 protein
IL17E protein
UNQ3120 protein
PRO10272 protein

Information sourced from Uniprot.org

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