| Function | Coreceptor for IL1RL2 in the IL-36 signaling system. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone.binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD. May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable). Isoform 2: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B.this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling. Isoform 4: Unable to mediate canonical IL-1 signaling. Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons. |
| Protein Name | Interleukin-1 Receptor Accessory ProteinIl-1 Receptor Accessory ProteinIl-1racpInterleukin-1 Receptor 3Il-1r-3Il-1r3 |
| Database Links | Reactome: R-HSA-1257604 Q9NPH3-1Reactome: R-HSA-388844 Q9NPH3-1Reactome: R-HSA-6811558 Q9NPH3-1Reactome: R-HSA-9014826 Q9NPH3-1Reactome: R-HSA-9014843 Q9NPH3-1Reactome: R-HSA-9020702 Q9NPH3-1 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: SecretedIsoform 3: Secreted |
| Alternative Protein Names | Interleukin-1 Receptor Accessory Protein proteinIl-1 Receptor Accessory Protein proteinIl-1racp proteinInterleukin-1 Receptor 3 proteinIl-1r-3 proteinIl-1r3 proteinIL1RAP proteinC3orf13 proteinIL1R3 protein |
Information sourced from Uniprot.org
