• Human IL12B (IL12B) Sandwich ELISA Kit (STJE0000008)

Human IL12B (IL12B) Sandwich ELISA Kit (STJE0000008)

SKU:
STJE0000008-96

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 1.95 pg/mL
Detection Limit: 1562-1000 pg/mL
Short Description: This IL12B Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Conjugation: Biotin
Storage Instruction: Unopened kits can be stored at 2-8°C for 1 year, and opened products must be used within 1 month.
Assay Time: 4 hours
Detection: Colorimetric
Gene Symbol: IL12B
Gene ID: 3593
Uniprot ID: IL12B_HUMAN
Sample Type: cell culture supernates, serum, EDTA plasma, Heparin plasma
Tissue Specificity
Post Translational Modifications Known to be C-mannosylated in the recombinant protein.it is not yet known for sure if the wild-type protein is also modified.
Function Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Protein Name Interleukin-12 Subunit Beta
Il-12b
Cytotoxic Lymphocyte Maturation Factor 40 Kda Subunit
Clmf P40
Il-12 Subunit P40
Nk Cell Stimulatory Factor Chain 2
Nksf2
Database Links Reactome: R-HSA-6783783
Reactome: R-HSA-6785807
Reactome: R-HSA-9020591
Reactome: R-HSA-9020933
Cellular Localisation Secreted
Alternative ELISA Names Interleukin-12 Subunit Beta ELISA kit
Il-12b ELISA kit
Cytotoxic Lymphocyte Maturation Factor 40 Kda Subunit ELISA kit
Clmf P40 ELISA kit
Il-12 Subunit P40 ELISA kit
Nk Cell Stimulatory Factor Chain 2 ELISA kit
Nksf2 ELISA kit
IL12B ELISA kit
NKSF2 ELISA kit
output

Information sourced from Uniprot.org

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