| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.112ng/mL |
| Detection Limit: |
0.312-20ng/mL |
| Short Description: |
This IL11Ra Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
IL11RA |
| Gene ID: |
3590 |
| Uniprot ID: |
I11RA_HUMAN |
| Sample Type: |
serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | Expressed in a number of cell lines, including the myelogenous leukemia cell line K-562, the megakaryocytic leukemia cell line M-07e, the erythroleukemia cell line TF-1, and the osteosarcoma cell lines, MG-63 and SaOS-2. Also expressed in normal and malignant prostate epithelial cell lines. Expression levels are increased in prostate carcinoma. |
| Post Translational Modifications | A short soluble form is also released from the membrane by proteolysis. The sIL11RA is formed either by limited proteolysis of membrane-bound receptors, a process referred to as ectodomain shedding, or directly secreted from the cells after alternative mRNA splicing. mIL11RA is cleaved by the proteases ADAM10, ELANE and PRTN3. |
| Function | Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable). Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. Soluble interleukin-11 receptor subunit alpha: Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling. Isoform HCR2: Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling. |
| Protein Name | Interleukin-11 Receptor Subunit AlphaIl-11 Receptor Subunit AlphaIl-11r Subunit AlphaIl-11r-AlphaIl-11ra Cleaved Into - Soluble Interleukin-11 Receptor Subunit AlphaSil-11rSil-11raSil11ra |
| Database Links | Reactome: R-HSA-6788467 |
| Cellular Localisation | Interleukin-11 Receptor Subunit Alpha: MembraneSingle-Pass Type I Membrane ProteinSoluble Interleukin-11 Receptor Subunit Alpha: SecretedIsoform Hcr2: Secreted |
| Alternative ELISA Names | Interleukin-11 Receptor Subunit Alpha ELISA kitIl-11 Receptor Subunit Alpha ELISA kitIl-11r Subunit Alpha ELISA kitIl-11r-Alpha ELISA kitIl-11ra Cleaved Into - Soluble Interleukin-11 Receptor Subunit Alpha ELISA kitSil-11r ELISA kitSil-11ra ELISA kitSil11ra ELISA kitIL11RA ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
