| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human IL-15-C-hFc protein was developed from hek293 cells and has a target region of C-hFc. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: |
Measured in a cell proliferation assay using HT-2 mouse T cells. The ED50 for this effect is 27-108 ng/mL, corresponding to a specific activity of 9.26 ×103-3.70×104 units/mg. |
| Gene Symbol: |
IL15 |
| Gene ID: |
3600 |
| Uniprot ID: |
IL15_HUMAN |
| Immunogen Region: |
Asn49-Ser162 |
| Immunogen: |
Recombinant Human IL-15 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asn49-Ser162) of Human IL-15 (Accession #NP_000576.1) fused with and a hFc tag at the C-terminus. |
| Function | Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems. Stimulates the proliferation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines. In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection. Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits. Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5. In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4. |
| Protein Name | Interleukin-15Il-15 |
| Database Links | Reactome: R-HSA-8983432 |
| Cellular Localisation | Isoform Il15-S48aa: SecretedIsoform Il15-S21aa: CytoplasmNucleusIl15-S21aa Is Not SecretedBut Rather Is Stored IntracellularlyAppearing In The Nucleus And Cytoplasmic Components |
| Alternative Protein Names | Interleukin-15 proteinIl-15 proteinIL15 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
