• Human IL-10 R alpha/IL10RA/CD210 protein (Recombinant) (C-RaFC) (STJP001841)
  • Human IL-10 R alpha/IL10RA/CD210 protein (Recombinant) (C-RaFC) (STJP001841)

Human IL-10 R alpha/IL10RA/CD210 protein (Recombinant) (C-RaFC) (STJP001841)

SKU:
STJP001841

£74.50 - £284.50
Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human IL-10 R alpha/IL10RA/CD210-C-RaFC protein was developed from hek293 cells and has a target region of C-RaFC. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity: Measured by its binding ability in a functional ELISA.Immobilized Human IL10 (Catalog: RP00093) at 2 Mu g/mL (100 Mu L/well) can bind Human IL10RA (Catalog: RP01648) with a linear range of 0.1-2.9 ng/mL.
Gene Symbol: IL10RA
Gene ID: 3587
Uniprot ID: I10R1_HUMAN
Immunogen Region: His22-Asn235
Immunogen: Active Recombinant Human IL-10 R alpha Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (His22-Asn235) of human IL-10 R alpha (Accession #NP_001549.2) fused with and a RaFc tag at the C-terminus.
Post Translational Modifications Phosphorylated. Phosphorylation of the cytoplasmic tail induced STAT3 activation. Ubiquitinated by BTRC.ubiquitination leads to endocytosis and subsequent degradation of IL10RA.
Function Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well. In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively. These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy.
Protein Name Interleukin-10 Receptor Subunit Alpha
Il-10 Receptor Subunit Alpha
Il-10r Subunit Alpha
Il-10ra
Cdw210a
Interleukin-10 Receptor Subunit 1
Il-10r Subunit 1
Il-10r1
Cd Antigen Cd210
Database Links Reactome: R-HSA-6783783
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cytoplasm
Alternative Protein Names Interleukin-10 Receptor Subunit Alpha protein
Il-10 Receptor Subunit Alpha protein
Il-10r Subunit Alpha protein
Il-10ra protein
Cdw210a protein
Interleukin-10 Receptor Subunit 1 protein
Il-10r Subunit 1 protein
Il-10r1 protein
Cd Antigen Cd210 protein
IL10RA protein
IL10R protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance