• Human IHH (Hedgehog Homolog, Indian) Sandwich ELISA Kit Ready-To-Use (STJE0016114)

Human IHH (Hedgehog Homolog, Indian) Sandwich ELISA Kit Ready-To-Use (STJE0016114)

SKU:
STJE0016114

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.057ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This IHH Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: IHH
Gene ID: 3549
Uniprot ID: IHH_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Expressed in embryonic lung, and in adult kidney and liver.
Post Translational Modifications Indian hedgehog protein N-product: Cholesterylation is required for N-product targeting to lipid rafts and multimerization. Indian hedgehog protein: The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product. The N-product is the active species in both local and long-range signaling, whereas the C-product is degraded in the reticulum endoplasmic. Indian hedgehog protein N-product: N-palmitoylation by HHAT of N-product is required for indian hedgehog protein N-product multimerization and full activity.
Function Indian hedgehog protein: The C-terminal part of the indian hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein into two parts followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product. Both activities occur in the reticulum endoplasmic. Plays a role in hedgehog paracrine signaling. Associated with the very-low-density lipoprotein (VLDL) particles to function as a circulating morphogen for endothelial cell integrity maintenance. Indian hedgehog protein N-product: The dually lipidated indian hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development. Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Plays a role in morphogenesis of the skeleton by coordinating growth and differentiation of the endochondral skeleton. Positively regulates PTHLH expression during endochondral bone formation preventing chondrocyte hypertrophy. In contrast, participates in normal chondrocyte proliferation in a PTHLH-independent pathway.
Protein Name Indian Hedgehog Protein
Ihh
Hhg-2 Cleaved Into - Indian Hedgehog Protein N-Product
Database Links Reactome: R-HSA-373080
Reactome: R-HSA-5358346
Reactome: R-HSA-5362798
Reactome: R-HSA-5632681
Reactome: R-HSA-5632684
Reactome: R-HSA-5635838
Reactome: R-HSA-5658034
Reactome: R-HSA-8941284
Reactome: R-HSA-9758920
Cellular Localisation Indian Hedgehog Protein N-Product: Cell Membrane
Lipid-Anchor
The N-Product Remains Associated With The Cell Surface
Indian Hedgehog Protein: Endoplasmic Reticulum Membrane
Golgi Apparatus Membrane
Secreted
Co-Localizes With Hhat In The Er And Golgi Membrane
Alternative ELISA Names Indian Hedgehog Protein ELISA kit
Ihh ELISA kit
Hhg-2 Cleaved Into - Indian Hedgehog Protein N-Product ELISA kit
IHH ELISA kit
output

Information sourced from Uniprot.org

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