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Human IGF2R protein (Recombinant) (C-His & Avi) (STJP002427)

Human IGF2R protein (Recombinant) (C-His & Avi) (STJP002427)
Human IGF2R protein (Recombinant) (C-His & Avi) (STJP002427)

Human IGF2R protein (Recombinant) (C-His & Avi) (STJP002427)

SKU:

STJP002427-100

€446.88

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General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human IGF2R-C-His & Avi protein was developed from hek293 cells and has a target region of C-His & Avi. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	IGF2R
Gene ID:	3482
Uniprot ID:	MPRI_HUMAN
Immunogen Region:	Glu47-Met1508
Immunogen:	Recombinant Human IGF2R Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu47-Met1508) of human IGF2R (Accession #NP_000867.2) fused with a His, Avi tag at the C-terminus.

Function	Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation by binding DPP4.
Protein Name	Cation-Independent Mannose-6-Phosphate Receptor Ci Man-6-P Receptor Ci-Mpr M6pr 300 Kda Mannose 6-Phosphate Receptor Mpr 300 Insulin-Like Growth Factor 2 Receptor Insulin-Like Growth Factor Ii Receptor Igf-Ii Receptor M6p/Igf2 Receptor M6p/Igf2r Cd Antigen Cd222
Database Links	Reactome: R-HSA-432722 Reactome: R-HSA-6798695 Reactome: R-HSA-6811440 Reactome: R-HSA-8856825 Reactome: R-HSA-8856828
Cellular Localisation	Golgi Apparatus Membrane Single-Pass Type I Membrane Protein Endosome Membrane Mainly Localized In The Golgi At Steady State And Not Detectable In Lysosome Colocalized With Dpp4 In Internalized Cytoplasmic Vesicles Adjacent To The Cell Surface
Alternative Protein Names	Cation-Independent Mannose-6-Phosphate Receptor protein Ci Man-6-P Receptor protein Ci-Mpr protein M6pr protein 300 Kda Mannose 6-Phosphate Receptor protein Mpr 300 protein Insulin-Like Growth Factor 2 Receptor protein Insulin-Like Growth Factor Ii Receptor protein Igf-Ii Receptor protein M6p/Igf2 Receptor protein M6p/Igf2r protein Cd Antigen Cd222 protein IGF2R protein MPRI protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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