• Human IGF1 (IGF1) Sandwich ELISA Kit (STJE0000085)

Human IGF1 (IGF1) Sandwich ELISA Kit (STJE0000085)

SKU:
STJE0000085-96

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.15 ng/mL
Detection Limit: 0312-20 ng/mL
Short Description: This IGF1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Conjugation: Biotin
Storage Instruction: Unopened kits can be stored at 2-8°C for 1 year, and opened products must be used within 1 month.
Assay Time: 4 hours
Detection: Colorimetric
Gene Symbol: IGF1
Gene ID: 3479
Uniprot ID: IGF1_HUMAN
Sample Type: serum, plasma and cell culture supernates
Tissue Specificity
Post Translational Modifications
Function The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of 1-14C-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1.
Protein Name Insulin-Like Growth Factor I
Igf-I
Mechano Growth Factor
Mgf
Somatomedin-C
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-2404192
Reactome: R-HSA-2428928
Reactome: R-HSA-2428933
Reactome: R-HSA-381426
Reactome: R-HSA-422085
Cellular Localisation Secreted
Alternative ELISA Names Insulin-Like Growth Factor I ELISA kit
Igf-I ELISA kit
Mechano Growth Factor ELISA kit
Mgf ELISA kit
Somatomedin-C ELISA kit
IGF1 ELISA kit
IBP1 ELISA kit
output

Information sourced from Uniprot.org

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