Human HGK2/CD167a protein (Recombinant) (C-His) (STJP002764)

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STJP002764

€111.88 - €468.13
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Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human HGK2/CD167a-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human DDR1 at 1 Mu g/mL (100 Mu L/well) can bind DDR1 Rabbit polyclonal antibody with a linear range of 1-205 ng/mL.
Gene Symbol: DDR1
Gene ID: 780
Uniprot ID: DDR1_HUMAN
Immunogen Region: Asp21-Ala417
Immunogen: Recombinant Human HGK2/CD167a Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp21-Ala417) of human DDR1 (Accession #NP_054699.2) fused with a 6×His tag at the C-terminus.
Post Translational Modifications Autophosphorylated in response to fibrillar collagen binding. Glycosylation of Asn-211, but apparently not of Asn-260 or Asn-394, prevents autophosphorylation from occurring in the absence of collagen.
Function Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.
Protein Name Epithelial Discoidin Domain-Containing Receptor 1
Epithelial Discoidin Domain Receptor 1
Cd167 Antigen-Like Family Member A
Cell Adhesion Kinase
Discoidin Receptor Tyrosine Kinase
Hgk2
Mammary Carcinoma Kinase 10
Mck-10
Protein-Tyrosine Kinase 3a
Protein-Tyrosine Kinase Rtk-6
Trk E
Tyrosine Kinase Ddr
Tyrosine-Protein Kinase Cak
Cd Antigen Cd167a
Database Links Reactome: R-HSA-3000171
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Cell Membrane
Isoform 3: Secreted
Isoform 4: Cell Membrane
Alternative Protein Names Epithelial Discoidin Domain-Containing Receptor 1 protein
Epithelial Discoidin Domain Receptor 1 protein
Cd167 Antigen-Like Family Member A protein
Cell Adhesion Kinase protein
Discoidin Receptor Tyrosine Kinase protein
Hgk2 protein
Mammary Carcinoma Kinase 10 protein
Mck-10 protein
Protein-Tyrosine Kinase 3a protein
Protein-Tyrosine Kinase Rtk-6 protein
Trk E protein
Tyrosine Kinase Ddr protein
Tyrosine-Protein Kinase Cak protein
Cd Antigen Cd167a protein
DDR1 protein
CAK protein
EDDR1 protein
NEP protein
NTRK4 protein
PTK3A protein
RTK6 protein
TRKE protein

Information sourced from Uniprot.org

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