Host: |
HEK293 cells |
Reactivity: |
Human |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Recombinant-Human HGK2/CD167a-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
Formulation: |
Supplied as a 0.22 Mu m filtered solution in PBS, pH 7.4. Contact us for customized product form or formulation. |
Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized Human DDR1 at 1 Mu g/mL (100 Mu L/well) can bind DDR1 Rabbit pAb with a linear range of 0.24-44.7 ng/mL. |
Gene Symbol: |
DDR1 |
Gene ID: |
780 |
Uniprot ID: |
DDR1_HUMAN |
Immunogen: |
Recombinant Human HGK2/CD167a Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp21-Ala417) of human DDR1 (Accession #NP_054699.2) fused with a 6×His tag at the C-terminus. |
Post Translational Modifications | Autophosphorylated in response to fibrillar collagen binding. Glycosylation of Asn-211, but apparently not of Asn-260 or Asn-394, prevents autophosphorylation from occurring in the absence of collagen. |
Function | Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. |
Protein Name | Epithelial Discoidin Domain-Containing Receptor 1Epithelial Discoidin Domain Receptor 1Cd167 Antigen-Like Family Member ACell Adhesion KinaseDiscoidin Receptor Tyrosine KinaseHgk2Mammary Carcinoma Kinase 10Mck-10Protein-Tyrosine Kinase 3aProtein-Tyrosine Kinase Rtk-6Trk ETyrosine Kinase DdrTyrosine-Protein Kinase CakCd Antigen Cd167a |
Database Links | Reactome: R-HSA-3000171 |
Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Cell MembraneIsoform 3: SecretedIsoform 4: Cell Membrane |
Alternative Protein Names | Epithelial Discoidin Domain-Containing Receptor 1 proteinEpithelial Discoidin Domain Receptor 1 proteinCd167 Antigen-Like Family Member A proteinCell Adhesion Kinase proteinDiscoidin Receptor Tyrosine Kinase proteinHgk2 proteinMammary Carcinoma Kinase 10 proteinMck-10 proteinProtein-Tyrosine Kinase 3a proteinProtein-Tyrosine Kinase Rtk-6 proteinTrk E proteinTyrosine Kinase Ddr proteinTyrosine-Protein Kinase Cak proteinCd Antigen Cd167a proteinDDR1 proteinCAK proteinEDDR1 proteinNEP proteinNTRK4 proteinPTK3A proteinRTK6 proteinTRKE protein |
Information sourced from Uniprot.org
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