• Human HDAC9 (Histone Deacetylase 9) Sandwich ELISA Kit Ready-To-Use (STJE0015804)

Human HDAC9 (Histone Deacetylase 9) Sandwich ELISA Kit Ready-To-Use (STJE0015804)

SKU:
STJE0015804

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.138ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This HDAC9 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: HDAC9
Gene ID: 9734
Uniprot ID: HDAC9_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Broadly expressed, with highest levels in brain, heart, muscle and testis. Isoform 3 is present in human bladder carcinoma cells (at protein level).
Post Translational Modifications Phosphorylated on Ser-220 and Ser-450.which promotes 14-3-3-binding, impairs interaction with MEF2, and antagonizes antimyogenic activity. Phosphorylated on Ser-240.which impairs nuclear accumulation. Isoform 7 is phosphorylated on Tyr-1010. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. Sumoylated.
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.
Protein Name Histone Deacetylase 9
Hd9
Histone Deacetylase 7b
Hd7
Hd7b
Histone Deacetylase-Related Protein
Mef2-Interacting Transcription Repressor Mitr
Database Links Reactome: R-HSA-2122947
Reactome: R-HSA-2644606
Reactome: R-HSA-2894862
Reactome: R-HSA-350054
Cellular Localisation Nucleus
Alternative ELISA Names Histone Deacetylase 9 ELISA kit
Hd9 ELISA kit
Histone Deacetylase 7b ELISA kit
Hd7 ELISA kit
Hd7b ELISA kit
Histone Deacetylase-Related Protein ELISA kit
Mef2-Interacting Transcription Repressor Mitr ELISA kit
HDAC9 ELISA kit
HDAC7 ELISA kit
HDAC7B ELISA kit
HDRP ELISA kit
KIAA0744 ELISA kit
MITR ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance