• Human HAS2 (Hyaluronan Synthase 2) Sandwich ELISA Kit (STJE0009391)

Human HAS2 (Hyaluronan Synthase 2) Sandwich ELISA Kit (STJE0009391)

SKU:
STJE0009391

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.115ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This HAS2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: HAS2
Gene ID: 3037
Uniprot ID: HYAS2_HUMAN
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Expressed in fibroblasts.
Post Translational Modifications Phosphorylation at Thr-328 is essential for hyaluronan synthase activity. Phosphorylation at Thr-110 is required for transport from ER to Golgi. O-GlcNAcylation at Ser-221 increases the stability of HAS2 and plasma membrane localization. Ubiquitination at Lys-190.this ubiquitination is essential for hyaluronan synthase activity and homo- or hetero-oligomerization. Can also be poly-ubiquitinated. Deubiquitinated by USP17 and USP4. USP17 efficiently removes 'Lys-63'- and 'Lys-48'-linked polyubiquitin chains, whereas USP4 preferentially removes monoubiquitination and, partially, both 'Lys-63'- and 'Lys-48'-linked polyubiquitin chain.
Function Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer (Probable). Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of three isoenzymes responsible for cellular hyaluronan synthesis and it is particularly responsible for the synthesis of high molecular mass hyaluronan.
Protein Name Hyaluronan Synthase 2
Hyaluronate Synthase 2
Hyaluronic Acid Synthase 2
Ha Synthase 2
Database Links Reactome: R-HSA-2142850
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Endoplasmic Reticulum Membrane
Vesicle
Golgi Apparatus Membrane
Lysosome
Travels From Endoplasmic Reticulum (Er)
Golgi To Plasma Membrane And Either Back To Endosomes And Lysosomes
Or Out Into Extracellular Vesicles
Post-Translational Modifications Control Has2 Trafficking
Alternative ELISA Names Hyaluronan Synthase 2 ELISA kit
Hyaluronate Synthase 2 ELISA kit
Hyaluronic Acid Synthase 2 ELISA kit
Ha Synthase 2 ELISA kit
HAS2 ELISA kit
output

Information sourced from Uniprot.org

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