| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
4.64pg/mL |
| Detection Limit: |
15.6-1000pg/mL |
| Short Description: |
This GRP Competitive ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
2.5 hrs |
| Gene Symbol: |
GRP |
| Gene ID: |
2922 |
| Uniprot ID: |
GRP_HUMAN |
| Sample Type: |
serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | |
| Function | Stimulates the release of gastrin and other gastrointestinal hormones. Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear. In another study, shown to act on vasoactive intestinal peptide (VIP)-expressing cells in the auditory cortex, most likely via extrasynaptic diffusion from local and long-range sources, to mediate disinhibition of glutamatergic cells via VIP cell-specific GRPR signaling which leads to enhanced auditory fear memories. Contributes to the regulation of food intake. Inhibits voltage-gated sodium channels but enhances voltage-gated potassium channels in hippocampal neurons. Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity. Neuromedin-C: Induces an itch response through activation of receptors present on mast cells, triggering mast cell degranulation. |
| Protein Name | Gastrin-Releasing PeptideGrp Cleaved Into - Neuromedin-CGrp-10Grp18-27 |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-381771Reactome: R-HSA-416476 |
| Cellular Localisation | SecretedCytoplasmic VesicleSecretory Vesicle LumenCell ProjectionNeuron ProjectionIn Neurons Of The Retrotrapezoid Nucleus/Parafacial Respiratory GroupExpressed On Neuron Projections Which Project Into The Pre-Botzinger Complex |
| Alternative ELISA Names | Gastrin-Releasing Peptide ELISA kitGrp Cleaved Into - Neuromedin-C ELISA kitGrp-10 ELISA kitGrp18-27 ELISA kitGRP ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
