• Human GRP (Gastrin Releasing Peptide) Competitive ELISA Kit Ready-To-Use (STJE0015703)

Human GRP (Gastrin Releasing Peptide) Competitive ELISA Kit Ready-To-Use (STJE0015703)

SKU:
STJE0015703

Shipping:
Free Shipping
Current Stock:
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 4.64pg/mL
Detection Limit: 15.6-1000pg/mL
Short Description: This GRP Competitive ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 2.5 hrs
Gene Symbol: GRP
Gene ID: 2922
Uniprot ID: GRP_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity
Post Translational Modifications
Function Stimulates the release of gastrin and other gastrointestinal hormones. Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear. In another study, shown to act on vasoactive intestinal peptide (VIP)-expressing cells in the auditory cortex, most likely via extrasynaptic diffusion from local and long-range sources, to mediate disinhibition of glutamatergic cells via VIP cell-specific GRPR signaling which leads to enhanced auditory fear memories. Contributes to the regulation of food intake. Inhibits voltage-gated sodium channels but enhances voltage-gated potassium channels in hippocampal neurons. Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity. Neuromedin-C: Induces an itch response through activation of receptors present on mast cells, triggering mast cell degranulation.
Protein Name Gastrin-Releasing Peptide
Grp Cleaved Into - Neuromedin-C
Grp-10
Grp18-27
Database Links Reactome: R-HSA-375276
Reactome: R-HSA-381771
Reactome: R-HSA-416476
Cellular Localisation Secreted
Cytoplasmic Vesicle
Secretory Vesicle Lumen
Cell Projection
Neuron Projection
In Neurons Of The Retrotrapezoid Nucleus/Parafacial Respiratory Group
Expressed On Neuron Projections Which Project Into The Pre-Botzinger Complex
Alternative ELISA Names Gastrin-Releasing Peptide ELISA kit
Grp Cleaved Into - Neuromedin-C ELISA kit
Grp-10 ELISA kit
Grp18-27 ELISA kit
GRP ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance