• Human FcgRT (Fc Fragment Of IgG Receptor Transporter Alpha) Sandwich ELISA Kit Ready-To-Use (STJE0015211)

Human FcgRT (Fc Fragment Of IgG Receptor Transporter Alpha) Sandwich ELISA Kit Ready-To-Use (STJE0015211)

SKU:
STJE0015211

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.127ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This FcgRT Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: FCGRT
Gene ID: 2217
Uniprot ID: FCGRN_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Expressed in full-term placenta, heart, lung, liver, muscle, kidney, pancreas, and both fetal and adult small intestine.
Post Translational Modifications
Function Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB. (Microbial infection) Acts as an uncoating receptor for a panel of echoviruses including Echovirus 5, 6, 7, 9, 11, 13, 25 and 29.
Protein Name Igg Receptor Fcrn Large Subunit P51
Fcrn
Igg Fc Fragment Receptor Transporter Alpha Chain
Neonatal Fc Receptor
Database Links
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Endosome Membrane
Alternative ELISA Names Igg Receptor Fcrn Large Subunit P51 ELISA kit
Fcrn ELISA kit
Igg Fc Fragment Receptor Transporter Alpha Chain ELISA kit
Neonatal Fc Receptor ELISA kit
FCGRT ELISA kit
FCRN ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance