• Human ENPP-3 (48-157) protein (Recombinant) (N-His & Avi) (STJP002395)
  • Human ENPP-3 (48-157) protein (Recombinant) (N-His & Avi) (STJP002395)
  • Human ENPP-3 (48-157) protein (Recombinant) (N-His & Avi) (STJP002395)

Human ENPP-3 (48-157) protein (Recombinant) (N-His & Avi) (STJP002395)

SKU:
STJP002395-100

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Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human ENPP-3 (48-157)-N-His & Avi protein was developed from hek293 cells and has a target region of N-His & Avi. For use in research applications.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Endotoxin: Less than 1EU per Mu g by the LAL method.
Gene Symbol: ENPP3
Gene ID: 5169
Uniprot ID: ENPP3_HUMAN
Immunogen Region: Leu48-Asp157
Immunogen: Recombinant Human ENPP-3 (48-157) Protein is expressed from Expi293 with His tag and Avi tag at the N-terminal.；It contains Leu48-Asp157.
Post Translational Modifications N-glycosylated. N-glycosylation is necessary for normal transport to the cell membrane, but is not the apical targeting signal.
Function Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP. Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells. Has also alkaline phosphodiesterase activity.
Protein Name Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 3
E-Npp 3
Npp3
Phosphodiesterase I Beta
Pd-Ibeta
Phosphodiesterase I/Nucleotide Pyrophosphatase 3
Cd Antigen Cd203c Includes - Alkaline Phosphodiesterase I - Nucleotide Pyrophosphatase
Nppase
Nucleotide Diphosphatase
Database Links Reactome: R-HSA-199220
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Apical Cell Membrane
Secreted
Detected At The Cell Surface Of Basophils
Detected At The Apical Plasma Membrane Of Bile Duct Cells
Located To The Apical Surface In Intestinal And Kidney Epithelial Cells
Secreted In Serum
And In Lumen Of Epithelial Cells
Alternative Protein Names Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 3 protein
E-Npp 3 protein
Npp3 protein
Phosphodiesterase I Beta protein
Pd-Ibeta protein
Phosphodiesterase I/Nucleotide Pyrophosphatase 3 protein
Cd Antigen Cd203c Includes - Alkaline Phosphodiesterase I - Nucleotide Pyrophosphatase protein
Nppase protein
Nucleotide Diphosphatase protein
ENPP3 protein
PDNP3 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance