Human DUT protein (Recombinant) (N-His) (STJP008945)

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STJP008945
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human DUT-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: DUT
Gene ID: 1854
Uniprot ID: DUT_HUMAN
Immunogen Region: Met112-Asn252
Immunogen: Homo sapiens (Human)
Post Translational Modifications Nuclear isoform 2 is phosphorylated in vivo on Ser-11, a reaction that can be catalyzed in vitro by CDC2. Phosphorylation in mature T-cells occurs in a cell cycle-dependent manner. Isoform 3 is not phosphorylated.
Function Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de novo thymidylate biosynthesis. Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor. Essential for embryonic development.
Protein Name Deoxyuridine 5'-Triphosphate Nucleotidohydrolase - Mitochondrial
Dutpase
Dutp Pyrophosphatase
Database Links Reactome: R-HSA-499943 P33316-2
Cellular Localisation Isoform 2: Nucleus
Isoform 3: Mitochondrion
Alternative Protein Names Deoxyuridine 5'-Triphosphate Nucleotidohydrolase - Mitochondrial protein
Dutpase protein
Dutp Pyrophosphatase protein
DUT protein

Information sourced from Uniprot.org

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