| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.122ng/mL |
| Detection Limit: |
0.312-20ng/mL |
| Short Description: |
This DUSP6 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
DUSP6 |
| Gene ID: |
1848 |
| Uniprot ID: |
DUS6_HUMAN |
| Sample Type: |
tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Expressed in keratinocytes (at protein level). |
| Post Translational Modifications | |
| Function | Inactivates MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia. Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain. Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors. |
| Protein Name | Dual Specificity Protein Phosphatase 6Dual Specificity Protein Phosphatase Pyst1Mitogen-Activated Protein Kinase Phosphatase 3Map Kinase Phosphatase 3Mkp-3 |
| Database Links | Reactome: R-HSA-112409Reactome: R-HSA-202670Reactome: R-HSA-5675221Reactome: R-HSA-9652817 |
| Cellular Localisation | Cytoplasm |
| Alternative ELISA Names | Dual Specificity Protein Phosphatase 6 ELISA kitDual Specificity Protein Phosphatase Pyst1 ELISA kitMitogen-Activated Protein Kinase Phosphatase 3 ELISA kitMap Kinase Phosphatase 3 ELISA kitMkp-3 ELISA kitDUSP6 ELISA kitMKP3 ELISA kitPYST1 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
