Human DKK3 protein (Recombinant) (N-His) (STJP006133)

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STJP006133
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human DKK3-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: DKK3
Gene ID: 27122
Uniprot ID: DKK3_HUMAN
Immunogen Region: Ala37-Ile350
Immunogen: Homo sapiens (Human)
Post Translational Modifications N- and O-glycosylated.
Function Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Protein Name Dickkopf-Related Protein 3
Dickkopf-3
Dkk-3
Hdkk-3
Cellular Localisation Secreted
Alternative Protein Names Dickkopf-Related Protein 3 protein
Dickkopf-3 protein
Dkk-3 protein
Hdkk-3 protein
DKK3 protein
REIC protein
UNQ258 protein
PRO295 protein

Information sourced from Uniprot.org

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