• Human DEFb126 (Defensin Beta 126) Sandwich ELISA Kit Ready-To-Use (STJE0014786)

Human DEFb126 (Defensin Beta 126) Sandwich ELISA Kit Ready-To-Use (STJE0014786)

SKU:
STJE0014786

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 34pg/mL
Detection Limit: 78.1-5000pg/mL
Short Description: This DEFb126 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: DEFB126
Gene ID: 81623
Uniprot ID: DB126_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity High-level and epididymis-specific expression. Expression is down-regulated in infertile men.
Post Translational Modifications O-glycosylated.glycans contain alpha(2,3)-linked sialic acids.
Function Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection.both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other surface components and allows sperm to penetrate the cumulus matrix and bind to the zona pellucida of the oocyte. In vitro has antimicrobial activity and may inhibit LPS-mediated inflammation.
Protein Name Beta-Defensin 126
Beta-Defensin 26
Defb-26
Defensin - Beta 126
Epididymal Secretory Protein 13.2
Esp13.2
Hbd26
Database Links Reactome: R-HSA-1461957
Reactome: R-HSA-1461973
Cellular Localisation Secreted
Secreted By Epididymal Cells And Is Absorbed To The Surface Of Sperm During Transit Through The Epididymis
Mainly Located On The Sperm Acrosome
Alternative ELISA Names Beta-Defensin 126 ELISA kit
Beta-Defensin 26 ELISA kit
Defb-26 ELISA kit
Defensin - Beta 126 ELISA kit
Epididymal Secretory Protein 13.2 ELISA kit
Esp13.2 ELISA kit
Hbd26 ELISA kit
DEFB126 ELISA kit
C20orf8 ELISA kit
DEFB26 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance