• Human DARC (Duffy Blood Group Chemokine Receptor) Sandwich ELISA Kit (STJE0008358)

Human DARC (Duffy Blood Group Chemokine Receptor) Sandwich ELISA Kit (STJE0008358)

SKU:
STJE0008358

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.062ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This DARC Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: ACKR1
Gene ID: 2532
Uniprot ID: ACKR1_HUMAN
Sample Type: serum, plasma, cell lysates or other biological fluids.
Tissue Specificity Found in adult kidney, adult spleen, bone marrow and fetal liver. In particular, it is expressed along postcapillary venules throughout the body, except in the adult liver. Erythroid cells and postcapillary venule endothelium are the principle tissues expressing duffy. Fy(-A-B) individuals do not express duffy in the bone marrow, however they do, in postcapillary venule endothelium.
Post Translational Modifications
Function Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes.when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
Protein Name Atypical Chemokine Receptor 1
Duffy Antigen/Chemokine Receptor
Fy Glycoprotein
Gpfy
Glycoprotein D
Plasmodium Vivax Receptor
Cd Antigen Cd234
Database Links Reactome: R-HSA-375276
Cellular Localisation Early Endosome
Recycling Endosome
Membrane
Multi-Pass Membrane Protein
Predominantly Localizes To Endocytic Vesicles
And Upon Stimulation By The Ligand Is Internalized Via Caveolae
Once Internalized
The Ligand Dissociates From The Receptor
And Is Targeted To Degradation While The Receptor Is Recycled Back To The Cell Membrane
Alternative ELISA Names Atypical Chemokine Receptor 1 ELISA kit
Duffy Antigen/Chemokine Receptor ELISA kit
Fy Glycoprotein ELISA kit
Gpfy ELISA kit
Glycoprotein D ELISA kit
Plasmodium Vivax Receptor ELISA kit
Cd Antigen Cd234 ELISA kit
ACKR1 ELISA kit
DARC ELISA kit
FY ELISA kit
GPD ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance