• Human CYP2D6 (Cytochrome P450 2D6) Sandwich ELISA Kit Ready-To-Use (STJE0014697)

Human CYP2D6 (Cytochrome P450 2D6) Sandwich ELISA Kit Ready-To-Use (STJE0014697)

SKU:
STJE0014697

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.049ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This CYP2D6 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: CYP2D6
Gene ID: 1565
Uniprot ID: CP2D6_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications
Function A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling. Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. Catalyzes the oxidative transformations of all-trans retinol to all-trans retinal, a precursor for the active form all-trans-retinoic acid. Also involved in the oxidative metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Protein Name Cytochrome P450 2d6
Cypiid6
Cholesterol 25-Hydroxylase
Cytochrome P450-Db1
Debrisoquine 4-Hydroxylase
Database Links Reactome: R-HSA-211935
Reactome: R-HSA-211958
Reactome: R-HSA-211981
Reactome: R-HSA-211999
Reactome: R-HSA-9027307
Reactome: R-HSA-9749641
Cellular Localisation Endoplasmic Reticulum Membrane
Peripheral Membrane Protein
Microsome Membrane
Alternative ELISA Names Cytochrome P450 2d6 ELISA kit
Cypiid6 ELISA kit
Cholesterol 25-Hydroxylase ELISA kit
Cytochrome P450-Db1 ELISA kit
Debrisoquine 4-Hydroxylase ELISA kit
CYP2D6 ELISA kit
CYP2DL1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance