| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.123ng/mL |
| Detection Limit: |
0.312-20ng/mL |
| Short Description: |
This CRNN Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
3 hrs |
| Gene Symbol: |
CRNN |
| Gene ID: |
49860 |
| Uniprot ID: |
CRNN_HUMAN |
| Immunogen Region: |
Ready-To-Use |
| Sample Type: |
tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Expressed in the basal skin layer (at protein level). Squamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of the granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular layer), inner root sheath of the hair follicle and in primary keratinocytes (at protein level). Expressed in the squamous epithelium of the cervix, esophagus, foreskin and larynx. Expressed in the fetal bladder and scalp skin. Expressed at very low levels in the lung, kidney, uterus, skeletal muscle, heart and fetal brain. Undetectable or barely detectable in esophageal and oral squamous cell carcinoma compared with the matched adjacent normal esophageal mucosa. Undetectable or barely detectable in larynx and esophagus from patients with pH-documented laryngopharyngeal reflux (LPR). |
| Post Translational Modifications | |
| Function | Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by pro-inflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways. |
| Protein Name | Cornulin53 Kda Putative Calcium-Binding Protein53 Kda Squamous Epithelial-Induced Stress Protein58 Kda Heat Shock ProteinSquamous Epithelial Heat Shock Protein 53Tumor-Related Protein |
| Database Links | |
| Cellular Localisation | CytoplasmDoes Not Colocalize With Tgm1 |
| Alternative ELISA Names | Cornulin ELISA kit53 Kda Putative Calcium-Binding Protein ELISA kit53 Kda Squamous Epithelial-Induced Stress Protein ELISA kit58 Kda Heat Shock Protein ELISA kitSquamous Epithelial Heat Shock Protein 53 ELISA kitTumor-Related Protein ELISA kitCRNN ELISA kitC1orf10 ELISA kitDRC1 ELISA kitPDRC1 ELISA kitSEP53 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
